Science
The immune system is critical for organismal healthspan. Immune cells patrol the entire body — surveilling for cancer and pathogens while mediating tissue regeneration and repair.
2024-01-16 18_21_56-higher quality image.pptx - Google Slides — Mozilla Firefox
We propose a better way, which addresses the root cause — the aging of the immune system. We rejuvenate the bone marrow stem cells (hematopoietic stem cells or HSCs) and other immune cell types, to prevent aging and treat many different diseases. Our approach may revolutionize the treatment of cancer, infectious disease, cardiovascular disease, and brain aging — the immune system governs aging at a systemic level.
img4-1 We have a method of >1000x expansion of human HSCs (maintaining stemless) that can transform the bone marrow transplant field — and this method allows us to produce large volumes of aged human HSCs and immune cells for high throughput combinatorial drug screening to find cocktails that rejuvenate cells ex vivo and in vivo.
Our team has two Nature papers on this breakthrough in HSC expansion technology.
img5-2 We have developed a series of assays to identify new molecules which regulate cellular aging and immune cell aging in particular.